Pdcd-4 (phospho Ser67) Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse,Rat,Monkey
Gen Adı
PDCD4
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | Pdcd-4 (phospho Ser67) Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse,Rat,Monkey |
| Konjugasyon | Unconjugated |
| Modifikasyon | Phosphorylated |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | PDCD4 |
| Alternatif İsimler | PDCD4; H731; Programmed cell death protein 4; Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a |
| Gen Kimliği | 27250 |
| SwissProt Kimliği | Q53EL6 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from human PDCD4 around the phosphorylation site of Ser67. AA range:33-82 |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000 |
| Moleküler Ağırlık | 56kDa |
Araştırma Alanı
Arka Plan
| This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010],caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Loss of expression correlated with tumor progression of lung and colon carcinoma.,domain:Binds EIF4A1 via the MA3 domains.,function:Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA.,induction:IL2 stimulation inhibits expression, while IL12 increases expression.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the PDCD4 family.,similarity:Contains 2 MI domains.,subcellular location:Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions. Exported from the nucleus in the absence of serum.,subunit:Interacts with EIF4A1 and EIF4A2.,tissue specificity:Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland., |
