WWOX Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse
Gen Adı
WWOX
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | WWOX Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | WWOX |
| Alternatif İsimler | WWOX; FOR; WOX1; WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase |
| Gen Kimliği | 51741 |
| SwissProt Kimliği | Q9NZC7 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from human WWOX. AA range:1-50 |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:10000-1:20000 |
| Moleküler Ağırlık | 47kDa |
Araştırma Alanı
| Cell Biology |
Arka Plan
| WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. skeletal system development,ossification,osteoblast differentiation,induction of apoptosis,steroid metabolic process,negative regulation of signal transduction,negative regulation of cell communication,regulation of cell death,positive regulation of cell death,induction of programmed cell death,regulation of Wnt receptor signaling pathway,negative regulation of Wnt receptor signaling pathway,regulation of apoptosis,positive regulation of apoptosis,regulation of programmed cell death,positive regulation of programmed cell death,skeletal system morphogenesis,oxidation reduction,bone development, |
