UTRO Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Rat,Mouse
Gen Adı
UTRN
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | UTRO Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Rat,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | UTRN |
| Alternatif İsimler | DMDL DRP1 |
| Gen Kimliği | 7402 |
| SwissProt Kimliği | P46939 |
| İmmünojen | Synthesized peptide derived from part region of human protein |
Uygulama
| Uygulama | IHC,ICC/IF |
| Seyreltme Oranı | IHC 1:50-1:300,ICC/IF 1:50-1:200 |
| Moleküler Ağırlık | 377kDa |
Araştırma Alanı
Arka Plan
| This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008],function:May play a role in anchoring the cytoskeleton to the plasma membrane.,online information:Utrophin entry,similarity:Contains 1 WW domain.,similarity:Contains 1 ZZ-type zinc finger.,similarity:Contains 2 CH (calponin-homology) domains.,similarity:Contains 20 spectrin repeats.,subcellular location:Neuromuscular junction.,subunit:Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM.,tissue specificity:Muscle., |
