TACC1 Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse
Gen Adı
TACC1
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | TACC1 Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | TACC1 |
| Alternatif İsimler | TACC1; KIAA1103; Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1 |
| Gen Kimliği | 6867 |
| SwissProt Kimliği | O75410 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from human TACC1. AA range:11-60 |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000 |
| Moleküler Ağırlık | 87kDa |
Araştırma Alanı
| Cell Biology; Cell Cycle; Markers; Epigenetics and Nuclear Signaling; Cell Differentiation |
Arka Plan
| This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009],alternative products:Additional isoforms seem to exist,developmental stage:Expressed at high level during early embryogenesis.,function:Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.,miscellaneous:Down-regulated in a subset of cases of breast cancer.,PTM:Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TACC family.,similarity:Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.,subcellular location:Nucleus during interphase. Weakly concentrated at centrosomes during mitosis.,subunit:Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.,tissue specificity:Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues., |
