SnoN Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse
Gen Adı
SKIL
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | SnoN Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | SKIL |
| Alternatif İsimler | SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein |
| Gen Kimliği | 6498 |
| SwissProt Kimliği | P12757 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665 |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:20000-1:40000 |
| Moleküler Ağırlık | 77kDa |
Araştırma Alanı
| Cancer; Oncoproteins/suppressors; Tumor suppressors; Epigenetics and Nuclear Signaling; Nuclear Signaling Pathways; SMADs |
Arka Plan
| The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],function:May have regulatory role in cell division or differentiation in response to extracellular signals.,similarity:Belongs to the SKI family.,subunit:Interacts with SMAD2, SMAD3 and RNF111.,tissue specificity:SNON and SNOA isoforms are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Expression of isoform SNOI is restricted to skeletal muscle., |
