Phospho-alpha Synuclein (Ser129) Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse,Rat
Gen Adı
SNCA
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | Phospho-alpha Synuclein (Ser129) Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse,Rat |
| Konjugasyon | Unconjugated |
| Modifikasyon | Phosphorylated |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3. |
| Saflaştırma | Affinity Purification |
Antijen Bilgisi
| Gen Adı | SNCA |
| Alternatif İsimler | SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP |
| Gen Kimliği | 6622 |
| SwissProt Kimliği | P37840 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from human Synuclein around the phosphorylation site of Ser129. AA range:91-140 |
Uygulama
| Uygulama | WB,IHC |
| Seyreltme Oranı | WB 1:500-1:1000,IHC 1:50-1:100 |
| Moleküler Ağırlık | Calculated MW: 14 kDa; Observed MW: 18 kDa |
Araştırma Alanı
| Neuroscience |
Arka Plan
| May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies). |
