Phospho-B23 (Thr199) Rabbit Polyclonal Antibody

Phospho-B23 (Thr199) Rabbit Polyclonal Antibody

Cat: APRab00844
Boyut:20μL Fiyat:$99_x000D_
Boyut:50μL Fiyat:$150_x000D_
Boyut:100μL Fiyat:$280_x000D_
Boyut:200μL Fiyat:$520_x000D_
Uygulama:WB,IHC,ICC/IF,ELISA
Reaktivite:Human,Mouse,Rat
Konjuge:Unconjugated
İsteğe bağlı konjugeler: Biotin, FITC (ücretsiz). Diğer 26 konjugatı görün.

Gen Adı:NPM1
Category: ポリクローナル抗体 Tags: , , , , , , , , , ,
Phospho-B23 (Thr199) Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
IHC  ICC/IF  ELISA WB,IHC,ICC/IF,ELISA
Reaktivite
Human,Mouse,Rat
Gen Adı
NPM1
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
Ürün Adı Phospho-B23 (Thr199) Rabbit Polyclonal Antibody
Açıklama Rabbit polyclonal Antibody
Konak Rabbit
Reaktivite Human,Mouse,Rat
Konjugasyon Unconjugated
Modifikasyon Phosphorylated
İzotip IgG
Klonalite Polyclonal
Form Liquid
Konsantrasyon Unconjugated
Saklama Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Nakliye Ice bags.
Tampon Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3.
Saflaştırma Affinity Chromatography
Antijen Bilgisi
Gen Adı NPM1
Alternatif İsimler B23; NPM
Gen Kimliği 4869
SwissProt Kimliği P06748
İmmünojen The antiserum was produced against synthesized peptide derived from human NPM around the phosphorylation site of Thr199. AA range:171-220
Uygulama
Uygulama WB,IHC,ICC/IF,ELISA
Seyreltme Oranı WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000
Moleküler Ağırlık Calculated MW: 33 kDa; Observed MW: 33 kDa
Araştırma Alanı
Epigenetics and Nuclear Signaling
Arka Plan
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
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