PDE10A Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Rat
Gen Adı
PDE10A
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | PDE10A Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Rat |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | PDE10A |
| Alternatif İsimler | PDE10A; cAMP and cAMP-inhibited cGMP 3'; 5'-cyclic phosphodiesterase 10A |
| Gen Kimliği | 10846 |
| SwissProt Kimliği | Q9Y233 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from human PDE10A. AA range:21-70 |
Uygulama
| Uygulama | WB,IHC,ELISA |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:50-1:300,ELISA 1:2000-1:20000 |
| Moleküler Ağırlık | 75kDa |
Araştırma Alanı
| Purine metabolism; |
Arka Plan
| The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011],alternative products:Isoforms differ in their N-terminal region,catalytic activity:Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 1 zinc ion.,domain:Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.,domain:The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity.,enzyme regulation:Inhibited by dipyridamole and moderately by IBMX. cAMP acts as an allosteric activator.,function:Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,pathway:Purine metabolism; cGMP degradation; GMP from cGMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,similarity:Contains 2 GAF domains.,subcellular location:Located mostly to soluble cellular fractions.,subunit:Homodimer.,tissue specificity:Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum., |
