PCNT Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse
Gen Adı
PCNT
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | PCNT Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | PCNT |
| Alternatif İsimler | KIAA0402 PCNT2 |
| Gen Kimliği | 5116 |
| SwissProt Kimliği | O95613 |
| İmmünojen | Synthesized peptide derived from part region of human protein |
Uygulama
| Uygulama | IHC,ICC/IF |
| Seyreltme Oranı | IHC 1:50-1:300,ICC/IF 1:50-1:200 |
| Moleküler Ağırlık | 366kDa |
Araştırma Alanı
| Cell Biology; Cell Cycle; Cell Division; Spindle; Tags & Cell Markers; Subcellular Markers; Organelles; Centrosome |
Arka Plan
| The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],disease:Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2) [MIM:210720]; also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence.,function:An integral component of the pericentriolar material (PCM).,subcellular location:Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization.,subunit:Interacts with PCM1. Binds calmodulin.,tissue specificity:Expressed in all tissues tested, including placenta, liver, kidney and thymus., |
