LRBA Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse
Gen Adı
LRBA
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | LRBA Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | LRBA |
| Alternatif İsimler | BGL CDC4L LBA |
| Gen Kimliği | 987 |
| SwissProt Kimliği | P50851 |
| İmmünojen | Synthesized peptide derived from human protein . at AA range: 1970-2050 |
Uygulama
| Uygulama | IHC,ICC/IF |
| Seyreltme Oranı | IHC 1:50-1:300,ICC/IF 1:50-1:200 |
| Moleküler Ağırlık | 314kDa |
Araştırma Alanı
Arka Plan
| The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],caution:Was originally (PubMed:1505956) said to be similar to yeast CDC4, but that similarity is very limited.,induction:By lipopolysaccharide (LPS).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 BEACH domain.,similarity:Contains 6 WD repeats., |
