EYA1/4 Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse
Gen Adı
EYA1/4
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | EYA1/4 Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3. |
| Saflaştırma | Affinity Purification |
Antijen Bilgisi
| Gen Adı | EYA1/4 |
| Alternatif İsimler | Eyes absent homolog 1; Eyes absent homolog 4 |
| Gen Kimliği | 2138/2070 |
| SwissProt Kimliği | Q99502/O95677 |
| İmmünojen | Synthetic peptide from human protein at AA range: 271-320 |
Uygulama
| Uygulama | IHC,ELISA |
| Seyreltme Oranı | IHC 1:50-1:100,ELISA 1:5000-1:20000 |
| Moleküler Ağırlık | - |
Araştırma Alanı
| Epigenetics and Nuclear Signaling |
Arka Plan
| Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. |
