ERR alpha Rabbit Monoclonal Antibody
Konjugasyon: Unconjugated
Recombinant rabbit monoclonal antibody
Uygulama
Reaktivite
Human, Mouse, Rat
Gen Adı
ESRRA
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | ERR alpha Rabbit Monoclonal Antibody |
| Açıklama | Recombinant rabbit monoclonal antibody |
| Konak | Rabbit |
| Reaktivite | Human, Mouse, Rat |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% protective protein. |
| Saflaştırma | Affinity Purification |
Antijen Bilgisi
| Gen Adı | ESRRA |
| Alternatif İsimler | ESRRA; ERRa; ERR1; HERR1; NR3B1; Steroid hormone receptor ERR1; ERR-alpha; ERRalpha; ESRL1; Estrogen receptor-like 1; Estrogen-related receptor alpha |
| Gen Kimliği | 2101 |
| SwissProt Kimliği | P11474 |
| İmmünojen | A synthetic peptide of human Estrogen Related Receptor alpha |
Uygulama
| Uygulama | WB,FC,IP |
| Seyreltme Oranı | WB 1:500-1:1000,FC 1:50-1:100,IP 1:20-1:50 |
| Moleküler Ağırlık | Calculated MW:46 kDa;Observed MW: 50 kDa |
Araştırma Alanı
| Epigenetics and Nuclear Signaling |
Arka Plan
| Estrogen-related receptor alpha (ERRα/NR3B1) is an orphan nuclear receptor that controls transcription of genes involved in fatty acid oxidation, glucose metabolism, and mitochondrial biogenesis. The receptor protein contains a non-conserved amino terminal domain (NTD), a central zinc finger DNA binding domain, and a ligand-binding domain. The carboxy-terminal AF2 helix motif of ERRα contains binding sites for nuclear receptor coactivators PGC-1α and PGC-1β. Research studies demonstrate that ERRα transcriptional activity is regulated through phosphorylation and sumoylation within the NTD. |
