CNOT4 Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Mouse,Rat
Gen Adı
CNOT4
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | CNOT4 Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse,Rat |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | CNOT4 |
| Alternatif İsimler | CNOT4; NOT4; CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp |
| Gen Kimliği | 4850 |
| SwissProt Kimliği | O95628 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from human CNOT4. AA range:61-110 |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:10000-1:20000 |
| Moleküler Ağırlık | 64kDa |
Araştırma Alanı
| RNA degradation; |
Arka Plan
| CCR4-NOT transcription complex subunit 4(CNOT4) Homo sapiens The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010],function:Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex.,pathway:Protein modification; protein ubiquitination.,PTM:Autoubiquitinated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Sequencing errors.,similarity:Contains 1 C3H1-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Binds CNOT1 via its C-terminus. Binds E2 ubiquitin ligases via its RING domain., |
