CD35 Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Rat,Mouse
Gen Adı
-
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | CD35 Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Rat,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | - |
| Alternatif İsimler | complement component (3b/4b) receptor 1/2 (Knops blood group) |
| Gen Kimliği | 1378 |
| SwissProt Kimliği | P17927/Q2VPA4 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from the Internal region of human CR1/CR1L. AA range:300-350 & 740-790 |
Uygulama
| Uygulama | WB,ELISA |
| Seyreltme Oranı | WB 1:500-1:2000,ELISA 1:10000-1:20000 |
| Moleküler Ağırlık | 220kDa |
Araştırma Alanı
| Complement and coagulation cascades;Hematopoietic cell lineage; |
Arka Plan
| This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variantsfunction:Mediates cellular binding of particles and immune complexes that have activated complement.,miscellaneous:This is the sequence of the F allotype of CR1.,online information:Blood group antigen gene mutation database,polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 30 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells., |
