CD158z Rabbit Polyclonal Antibody
Konjugasyon: Unconjugated
Rabbit polyclonal Antibody
Uygulama
Reaktivite
Human,Rat,Mouse
Gen Adı
KIR3DL3
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | CD158z Rabbit Polyclonal Antibody |
| Açıklama | Rabbit polyclonal Antibody |
| Konak | Rabbit |
| Reaktivite | Human,Rat,Mouse |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Polyclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | KIR3DL3 |
| Alternatif İsimler | KIR3DL3; CD158Z; KIR3DL7; KIRC1; Killer cell immunoglobulin-like receptor 3DL3; CD158 antigen-like family member Z; Killer cell inhibitory receptor 1; CD158z |
| Gen Kimliği | 100133046 |
| SwissProt Kimliği | Q8N743 |
| İmmünojen | The antiserum was produced against synthesized peptide derived from the Internal region of human KIR3DL3. AA range:231-280 |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:10000-1:20000 |
| Moleküler Ağırlık | 45kDa |
Araştırma Alanı
| Antigen processing and presentation; |
Arka Plan
| killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3(KIR3DL3) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack thefunction:Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., |
