p7S6 Kinase (Phospho-Ser 411) Mouse Monoclonal Antibody
Konjugasyon: Unconjugated
Mouse monoclonal Antibody
Uygulama
Reaktivite
Human, Mouse, Rat
Gen Adı
p7S6 Kinase (Phospho-Ser 411)
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | p7S6 Kinase (Phospho-Ser 411) Mouse Monoclonal Antibody |
| Açıklama | Mouse monoclonal Antibody |
| Konak | Mouse |
| Reaktivite | Human, Mouse, Rat |
| Konjugasyon | Unconjugated |
| Modifikasyon | Phosphorylated |
| İzotip | IgG |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Purified antibody in TBS with 0.05% sodium azide,1%protective protein and 50% glycerol. |
| Saflaştırma | Affinity Purification |
Antijen Bilgisi
| Gen Adı | p7S6 Kinase (Phospho-Ser 411) |
| Alternatif İsimler | 70 kDa ribosomal protein S6 kinase 2 antibody EC 2.7.11.1 antibody KS6B2_HUMAN antibody p70 beta antibody p70 ribosomal S6 kinase beta antibody p70 S6 kinase beta antibody p70 S6K-beta antibody p70 S6KB antibody p70 S6Kbeta antibody p70(S6K) beta antibody p70-beta antibody p70-S6K 2 antibody P70S6K2 antibody p70S6Kb antibody Ribosomal protein S6 kinase 70kDa, polypeptide 2 antibody Ribosomal protein S6 kinase beta 2 antibody Ribosomal protein S6 kinase beta-2 antibody Rps6kb2 antibody S6 kinase related kinase antibody S6 kinase-related kinase antibody S6K beta 2 antibody S6K beta antibody S6K-beta antibody S6K-beta-2 antibody S6K2 antibody Serine/threonine protein kinase 14 beta antibody Serine/threonine-protein kinase 14B antibody SRK antibody STK14B antibody |
| Gen Kimliği | 6199; |
| SwissProt Kimliği | Q9UBS0 |
| İmmünojen | A sequence containing Ser 411 phosphorylated p70 S6 kinase α isoform 2 of human origin. |
Uygulama
| Uygulama | WB,IHC,ICC,IP |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:50-1:500,ICC 1:100-1:500,IP 1:20-1:50 |
| Moleküler Ağırlık | 70kDa |
Araştırma Alanı
| PI3K-Akt signaling pathway |
Arka Plan
| In studies to elucidate key regulatory pathways in signal transduction, several protein serine/threonine (Ser/Thr) kinases have been identified. Included among such kinases are two distinct families of 40S ribosomal protein S6 Ser/Thr kinases present in somatic animal cells, designated p70 S6 kinase and p90 Rsk kinase. p90 Rsk kinase is maximally activated within minutes of addition of growth factors or phorbol ester to cultured cells followed by activation of p70 S6 kinase. Both enzymes are regulated by serine/threonine phosphorylation, suggesting that specific kinases may exist upstream in the signaling pathway that regulate these kinases. In fact, evidence suggests that one such family of activating enzymes includes the members of the ERK MAP kinase family. The ERK MAP kinases are, in turn, regulated by phosphorylation at threonine and tyrosine residues by a protein kinase designated MEK. |
