TGFB2 Mouse Monoclonal Antibody
Konjugasyon: Unconjugated
Mouse monoclonal Antibody
Uygulama
Reaktivite
Human
Gen Adı
TGFB2
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | TGFB2 Mouse Monoclonal Antibody |
| Açıklama | Mouse monoclonal Antibody |
| Konak | Mouse |
| Reaktivite | Human |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | Mouse IgG1 |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Purified antibody in TBS with 0.05% sodium azide. |
| Saflaştırma | Affinity Purification |
Antijen Bilgisi
| Gen Adı | TGFB2 |
| Alternatif İsimler | Transforming growth factor beta-2, TGF-beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin, Latency-associated peptide, LAP, TGFB2 |
| Gen Kimliği | 7042 |
| SwissProt Kimliği | P61812 |
| İmmünojen | This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein. |
Uygulama
| Uygulama | WB,IHC,ICC |
| Seyreltme Oranı | WB 1:500-1:1000,IHC 1:100-1:500,ICC 1:20-1:50 |
| Moleküler Ağırlık | 47.7kDa |
Araştırma Alanı
| TGF-beta signaling pathway,MAPK signaling pathway |
Arka Plan
| This gene encodes a member of the transforming growthfactor beta (TGFB) family of cytokines, which are multifunctionalpeptides that regulate proliferation, differentiation, adhesion,migration, and other functions in many cell types by transducingtheir signal through combinations of transmembrane type I and typeII receptors (TGFBR1 and TGFBR2) and their downstream effectors,the SMAD proteins. Disruption of the TGFB/SMAD pathway has beenimplicated in a variety of human cancers. The encoded protein issecreted and has suppressive effects of interleukin-2 dependentT-cell growth. Translocation t(1;7)(q41;p21) between this gene andHDAC9 is associated with Peters' anomaly, a congenital defect ofthe anterior chamber of the eye. The knockout mice lacking thisgene show perinatal mortality and a wide range of developmental,including cardiac, defects. Alternatively spliced transcriptvariants encoding different isoforms have been identified. |
