Smad2 (Phospho Ser250) Rabbit Monoclonal Antibody
Konjugasyon: Phospho
Recombinant rabbit monoclonal antibody
Uygulama
Reaktivite
Human,Mouse,Rat
Gen Adı
SMAD2
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | Smad2 (Phospho Ser250) Rabbit Monoclonal Antibody |
| Açıklama | Recombinant rabbit monoclonal antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse,Rat |
| Konjugasyon | Phospho |
| Modifikasyon | Phosphorylated |
| İzotip | IgG,Kappa |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Phospho |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%protective protein |
| Saflaştırma | Protein A |
Antijen Bilgisi
| Gen Adı | SMAD2 |
| Alternatif İsimler | SMAD2;MADH2;MADR2;Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2 |
| Gen Kimliği | 4087 |
| SwissProt Kimliği | Q15796 |
| İmmünojen | A synthetic Phosphorylated peptide corresponding to residues target protein |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA,IP |
| Seyreltme Oranı | WB 1:1000-1:5000,IHC 1:100-1:500,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
| Moleküler Ağırlık | Calculated MW:58kD;Observed MW:58kD |
Araştırma Alanı
Arka Plan
| Cell localization:Cytoplasm, Nuclear.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation |
