STAT3 Rabbit Monoclonal Antibody
Konjugasyon: Unconjugated
Recombinant rabbit monoclonal antibody
Uygulama
Reaktivite
Human,Mouse,Rat
Gen Adı
STAT3
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | STAT3 Rabbit Monoclonal Antibody |
| Açıklama | Recombinant rabbit monoclonal antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse,Rat |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG,Kappa |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%protective protein |
| Saflaştırma | Protein A |
Antijen Bilgisi
| Gen Adı | STAT3 |
| Alternatif İsimler | STAT3;APRF;Signal transducer and activator of transcription 3;Acute-phase response factor |
| Gen Kimliği | 6774 |
| SwissProt Kimliği | P40763 |
| İmmünojen | A synthetic peptide corresponding to target protein |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA,IP |
| Seyreltme Oranı | WB 1:1000-1:5000,IHC 1:100-1:500,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
| Moleküler Ağırlık | Calculated MW:88kD;Observed MW:88kD |
Araştırma Alanı
Arka Plan
| Cell localization:Cytoplasm, Nucleus.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper |
