MEK3 Rabbit Monoclonal Antibody
Konjugasyon: Unconjugated
Recombinant rabbit monoclonal antibody
Uygulama
Reaktivite
Human,Mouse,Rat
Gen Adı
MAP2K3
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | MEK3 Rabbit Monoclonal Antibody |
| Açıklama | Recombinant rabbit monoclonal antibody |
| Konak | Rabbit |
| Reaktivite | Human,Mouse,Rat |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG,Kappa |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%protective protein |
| Saflaştırma | Protein A |
Antijen Bilgisi
| Gen Adı | MAP2K3 |
| Alternatif İsimler | MAP2K3;MEK3;MKK3;PRKMK3;SKK2;Dual specificity mitogen-activated protein kinase kinase 3;MAP kinase kinase 3;MAPKK 3;MAPK/ERK kinase 3;MEK 3;Stress-activated protein kinase kinase 2;SAPK kinase 2;SAPKK-2;SAPKK2 |
| Gen Kimliği | 5606 |
| SwissProt Kimliği | P46734 |
| İmmünojen | Recombinant protein of human MEK3 |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA,IP |
| Seyreltme Oranı | WB 1:2000-1:10000,IHC 1:200-1:1000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
| Moleküler Ağırlık | Calculated MW:39kD;Observed MW:39kD |
Araştırma Alanı
Arka Plan
| Cell localization:Cytoplasm, Nucleus.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008], |
