IGF1R Mouse Monoclonal Antibody
Konjugasyon: Unconjugated
Mouse monoclonal Antibody
Uygulama
Reaktivite
Human
Gen Adı
IGF1R
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | IGF1R Mouse Monoclonal Antibody |
| Açıklama | Mouse monoclonal Antibody |
| Konak | Mouse |
| Reaktivite | Human |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | Mouse IgG2a |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Purified antibody in PBS with 0.05% sodium azide |
| Saflaştırma | Affinity Purification |
Antijen Bilgisi
| Gen Adı | IGF1R |
| Alternatif İsimler | IGFR; CD221; IGFIR; JTK13 |
| Gen Kimliği | 3480 |
| SwissProt Kimliği | P08069 |
| İmmünojen | Purified recombinant fragment of human IGF1R (AA: extra(741-935)) expressed in E. Coli. |
Uygulama
| Uygulama | WB,ELISA,FC |
| Seyreltme Oranı | WB 1:500-1:2000,ELISA 1:5000-1:20000,FC 1:200-1:400 |
| Moleküler Ağırlık | 154.8kDa |
Araştırma Alanı
| PI3K-Akt signaling pathway,Jak-STAT signaling pathway,Hippo signaling pathway |
Arka Plan
| This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
