FCGR3A Mouse Monoclonal Antibody
Konjugasyon: Unconjugated
Mouse monoclonal Antibody
Uygulama
Reaktivite
Human
Gen Adı
FCGR3A
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | FCGR3A Mouse Monoclonal Antibody |
| Açıklama | Mouse monoclonal Antibody |
| Konak | Mouse |
| Reaktivite | Human |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | Mouse IgG1 |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Purified antibody in PBS with 0.05% sodium azide. |
| Saflaştırma | Affinity Purification |
Antijen Bilgisi
| Gen Adı | FCGR3A |
| Alternatif İsimler | Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3 |
| Gen Kimliği | 2214 |
| SwissProt Kimliği | P08637 |
| İmmünojen | This FCGR3A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from human FCGR3A. |
Uygulama
| Uygulama | WB |
| Seyreltme Oranı | WB 1:500-1:1000 |
| Moleküler Ağırlık | 29.1kDa |
Araştırma Alanı
Arka Plan
| This gene encodes a receptor for the Fc portion ofimmunoglobulin G, and it is involved in the removal ofantigen-antibody complexes from the circulation, as well as otherother antibody-dependent responses. This gene (FCGR3A) is highlysimilar to another nearby gene (FCGR3B) located on chromosome 1.The receptor encoded by this gene is expressed on natural killer(NK) cells as an integral membrane glycoprotein anchored through atransmembrane peptide, whereas FCGR3B is expressed onpolymorphonuclear neutrophils (PMN) where the receptor is anchoredthrough a phosphatidylinositol (PI) linkage. Mutations in this genehave been linked to susceptibility to recurrent viral infections,susceptibility to systemic lupus erythematosus, and alloimmuneneonatal neutropenia. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene. |
