DR5 (3Q11) Rabbit Monoclonal Antibody
Konjugasyon: Unconjugated
Recombinant rabbit monoclonal antibody
Uygulama
Reaktivite
Human
Gen Adı
TNFRSF10B
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | DR5 (3Q11) Rabbit Monoclonal Antibody |
| Açıklama | Recombinant rabbit monoclonal antibody |
| Konak | Rabbit |
| Reaktivite | Human |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% protective protein. |
| Saflaştırma | Affinity purification |
Antijen Bilgisi
| Gen Adı | TNFRSF10B |
| Alternatif İsimler | Death receptor 5; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; |
| Gen Kimliği | 8795 |
| SwissProt Kimliği | O14763 |
| İmmünojen | A synthetic peptide of human DR5 |
Uygulama
| Uygulama | WB,IHC,IP,IF-P |
| Seyreltme Oranı | WB 1:500-1:2000,IHC 1:200-1:2000,IP 1:20-1:50,IF-P 1:200-1:2000 |
| Moleküler Ağırlık | 49kDa |
Araştırma Alanı
| Cell Biology |
Arka Plan
| Plays an important role in the regulation of apoptosis in various physiological systems. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
