Collagen IV Rabbit Monoclonal Antibody
Konjugasyon: Unconjugated
Recombinant rabbit monoclonal antibody
Uygulama
Reaktivite
Human
Gen Adı
COL4A1
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | Collagen IV Rabbit Monoclonal Antibody |
| Açıklama | Recombinant rabbit monoclonal antibody |
| Konak | Rabbit |
| Reaktivite | Human |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | IgG,Kappa |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%protective protein |
| Saflaştırma | Protein A |
Antijen Bilgisi
| Gen Adı | COL4A1 |
| Alternatif İsimler | Arresten;BSVD;CO4A1_HUMAN;COL4A1;COL4A1 NC1 domain;COL4A2;COL4A3;COL4A4;COL4A5;collagen alpha-1;IV;chain;Collagen IV Alpha 1 Polypeptide;Collagen IV Alpha 2 Polypeptide;Collagen Of Basement Membrane Alpha 1 Chain;Collagen Of Basement Membrane Alpha 2 Chain;Collagen Type IV Alpha 1;collagen type IV alpha 1 chain;Collagen Type IV Alpha 2;Collagen Type IV Alpha 3;Collagen Type IV Alpha 4;Collagen Type IV Alpha 5;RatOR |
| Gen Kimliği | 1282 |
| SwissProt Kimliği | P02462 |
| İmmünojen | A synthetic peptide of human Collagen IV |
Uygulama
| Uygulama | WB,IHC,ICC/IF,ELISA,IP |
| Seyreltme Oranı | WB 1:1000-1:5000,IHC 1:200-1:1000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
| Moleküler Ağırlık | Calculated MW:160kD;Observed MW:200kD |
Araştırma Alanı
Arka Plan
| Cell localization:Cytoplasmic.This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014], |
