C-MYC Mouse Monoclonal Antibody
Konjugasyon: Unconjugated
Mouse monoclonal Antibody
Uygulama
Reaktivite
Human
Gen Adı
C-MYC
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
| Ürün Adı | C-MYC Mouse Monoclonal Antibody |
| Açıklama | Mouse monoclonal Antibody |
| Konak | Mouse |
| Reaktivite | Human |
| Konjugasyon | Unconjugated |
| Modifikasyon | Unmodified |
| İzotip | Mouse IgG1 |
| Klonalite | Monoclonal |
| Form | Liquid |
| Konsantrasyon | Unconjugated |
| Saklama | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
| Nakliye | Ice bags. |
| Tampon | Purified antibody in PBS with 0.05% sodium azide |
| Saflaştırma | Affinity Purification |
Antijen Bilgisi
| Gen Adı | C-MYC |
| Alternatif İsimler | MRTL; MYCC; c-Myc; bHLHe39 |
| Gen Kimliği | 4609 |
| SwissProt Kimliği | P01106 |
| İmmünojen | Purified recombinant fragment of human C-MYC (AA: (290-439)) expressed in E. Coli. |
Uygulama
| Uygulama | IHC,ELISA,FC |
| Seyreltme Oranı | IHC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400 |
| Moleküler Ağırlık | 32.1/57/48.8kDa |
Araştırma Alanı
| PI3K-Akt signaling pathway,MAPK signaling pathway |
Arka Plan
| This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017] |
