ANP (19C4) Rabbit Monoclonal Antibody

ANP (19C4) Rabbit Monoclonal Antibody

Cat: AMRe06936
Boyut:50μL Fiyat:$128_x000D_
Boyut:100μL Fiyat:$230_x000D_
Boyut:200μL Fiyat:$380_x000D_
Uygulama:WB,IHC,IP,IF-P
Reaktivite:Human,Rat
Konjuge:Unconjugated
İsteğe bağlı konjugeler: Biotin, FITC (ücretsiz). Diğer 26 konjugatı görün.

Gen Adı:NPPA
Category: 組換えモノクローナル抗体 Tags: , , , , , , , ,
ANP (19C4) Rabbit Monoclonal Antibody
Konjugasyon: Unconjugated
Recombinant rabbit monoclonal antibody
Uygulama
IHC  ICC/IF  ELISA WB,IHC,IP,IF-P
Reaktivite
Human,Rat
Gen Adı
NPPA
Saklama
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Özet
Ürün Adı ANP (19C4) Rabbit Monoclonal Antibody
Açıklama Recombinant rabbit monoclonal antibody
Konak Rabbit
Reaktivite Human,Rat
Konjugasyon Unconjugated
Modifikasyon Unmodified
İzotip IgG
Klonalite Monoclonal
Form Liquid
Konsantrasyon Unconjugated
Saklama Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles.
Nakliye Ice bags.
Tampon Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Saflaştırma Affinity purification
Antijen Bilgisi
Gen Adı NPPA
Alternatif İsimler ANF; ANP; PND; ATFB6; CDD-ANF; NPPA; Natriuretic peptides A; LANP; VSDL;
Gen Kimliği 4878
SwissProt Kimliği P01160
İmmünojen Recombinant protein of human ANP
Uygulama
Uygulama WB,IHC,IP,IF-P
Seyreltme Oranı WB 1:500-1:2000,IHC 1:500-1:2000,IP 1:20-1:50,IF-P 1:500-1:2000
Moleküler Ağırlık 16kDa
Araştırma Alanı
Arka Plan
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. [Atrial natriuretic peptide]: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (PubMed:8653797, PubMed:7595132, PubMed:2825692, PubMed:7720651, PubMed:8087923, PubMed:2532366, PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263, PubMed:16875975). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (PubMed:25401746, PubMed:9893117, PubMed:1672777, PubMed:1660465, PubMed:2162527, PubMed:2825692, PubMed:7720651, PubMed:22307324, PubMed:8384600, PubMed:21098034). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (PubMed:8653797, PubMed:7595132, PubMed:2825692, PubMed:7720651, PubMed:2532366, PubMed:8087923). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (PubMed:16875975). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263). This includes upregulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263). Binds the clearance receptor NPR3 which removes the hormone from circulation (PubMed:1672777).
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