SHP‑2 (PTPN11) is a ubiquitously expressed, nonreceptor protein tyrosine phosphatase (PTP). It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens, and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP‑2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines. In addition to its role in Gab1‑mediated Erk activation, SHP‑2 attenuates EGF‑dependent PI3 kinase activation by dephosphorylating Gab1 at p85 binding sites. SHP‑2 becomes phosphorylated at Tyr542 and Tyr580 in its carboxy terminus in response to growth factor receptor activation. These phosphorylation events are thought to relieve basal inhibition and stimulate SHP‑2 tyrosine phosphatase activity. Mutations in the corresponding gene result in a pair of clinically similar disorders (Noonan syndrome and LEOPARD syndrome) that may result from abnormal MAPK regulation.
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| SHP2 | AMRe85131 | SHP2 Rabbit Monoclonal Antibody | Human | WB,IHC,IP |
| Phospho‑SHP2 (Y542) | AMRe06005 | Phospho‑SHP2 (Y542) (7K17) Rabbit Monoclonal Antibody | Human,Mouse | WB,ICC/IF,IP |
| SHP2 | AMRe86995 | SHP2 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IP |
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References
- The SHP‑2 tyrosine phosphatase: signaling mechanisms and biological functions. Qu CK. Cell Res. 2000. [PMID: 11191350]
- The tyrosine phosphatase SHP‑2 is required for sustained activation of extracellular signal‑regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Maroun CR, et al. Mol Cell Biol. 2000. [PMID: 11046147]
- Receptor‑specific regulation of phosphatidylinositol 3'‑kinase activation by the protein tyrosine phosphatase Shp2. Zhang SQ, et al. Mol Cell Biol. 2002. [PMID: 12024020]
- Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP‑2. Zhang H, et al. Mini Rev Med Chem. 2020. [PMID: 32124695]
- Protein‑tyrosine‑phosphatase SHPTP2 couples platelet‑derived growth factor receptor beta to Ras. Bennett AM, et al. Proc Natl Acad Sci U S A. 1994 . [PMID: 8041791]
- Site‑specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP‑2 in cell signaling. Lu W, et al. Mol Cell. 2001. [PMID: 11684012]
- How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms? Edouard T, et al. Cell Mol Life Sci. 2007. [PMID: 17453145]
