チクングニヤウイルス
チクングニヤウイルス
チクングニヤウイルス（CHIKV）は主に発熱、関節痛、発疹を引き起こす蚊媒介性病原体です。地球温暖化により蚊の媒介範囲が拡大するにつれ、CHIKVは蔓延し続け、公衆衛生に対する脅威がますます深刻になっています。CHIKV感染と闘うため、我々は高感度・特異的なチクングニヤウイルスの抗原・抗体試薬を発売し、CHIKVワクチン開発、抗ウイルス薬発見、診断アッセイ開発に包括的なサポートを提供しています。
ウイルス特性： チクングニヤウイルス（CHIKV）はトガウイルス科アルファウイルス属に分類される、エンベロープを持つ一本鎖プラス鎖RNAウイルスです。ウイリオンは球形で、直径約60-70nmで、二十面体対称の脂質エンベロープを持ちます。ゲノムの長さは約11.6-11.8kbで、5'末端に7-メチルグアノシンキャップが付加され、3'末端はポリアデニル化されています。4つの非構造タンパク質（nsP1、nsP2、nsP3、nsP4）と5つの構造タンパク質（カプシドおよびエンベロープ糖タンパク質E1、E2、E3、および6K）をコードしています。カプシドタンパク質の240コピーで形成されるヌクレオカプシドコアはゲノムRNAを包み込み、外側のエンベロープにはE1/E2ヘテロダイマーからなる80個の三量体スパイクが表示されています。E2糖タンパク質は宿主細胞レセプターへの結合を仲介し、E1糖タンパク質は膜融合を駆動します。CHIKVは主にAedes aegyptiおよびAedes albopictus蚊によって伝播されます。熱、乾燥、一般的な消毒薬に敏感で、複数のジェノタイプが存在します。その中でもECSAジェノタイプのE1-A226V変異はA. albopictusへの適応性を高めます。
チクングニヤウイルスのゲノム構造、タンパク質発現、およびウイルス集合
製品の特徴
高純度
厳格な品質管理により90%以上の純度を保証
安定性
バッチ間の高い一貫性
チクングニヤウイルス組換え抗原リスト
| Cat. # | 製品名 | 純度 | Gene# | 宿主/発現系 |
|---|---|---|---|---|
| PEV60000 | Recombinant CHIKV NSP2 Protein, N-GST-His | >90% as determined by SDS-PAGE | A6MH24 | E.coli |
| PHV60001 | Recombinant CHIKV Spike glycoprotein E1 Protein, C-Fc | >90% as determined by SDS-PAGE | Q8JUX5 | Mammalian cells |
| PHV60002 | Recombinant CHIKV Spike glycoprotein E2 Protein, C-Fc | >90% as determined by SDS-PAGE | Q8JUX5 | Mammalian cells |
| PHV60003 | Recombinant CHIKV Spike glycoprotein E2 Protein, C-His | >90% as determined by SDS-PAGE | AIL00833.1 | Mammalian cells |
チクングニヤウイルス抗体リスト
| Cat. # | 製品名 | 標的 | 反応性 | アイソタイプ | アプリケーション |
|---|---|---|---|---|---|
| AMRe60066 | CHIKV p130/Structural polyprotein Recombinant Antibody (9.8B) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV), Chikungunya virus (strain Nagpur) (CHIKV), Chikungunya virus (strain 37997) (CHIKV) | IgG1, kappa | Neutralization |
| AMRe60067 | CHIKV p130/Structural polyprotein Recombinant Antibody (CHK152) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV), Chikungunya virus (strain Nagpur) (CHIKV), Chikungunya virus (strain 37997) (CHIKV) | IgG1, kappa | Neutralization |
| AMRe60068 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC1.370) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | FC |
| AMRe60069 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC1.380) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | FC, IP |
| AMRe60070 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC1.415) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | FC |
| AMRe60071 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC1.55) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA, FC |
| AMRe60072 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC1.56) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | FC, IP |
| AMRe60073 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC1.7) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA, FC, IP |
| AMRe60074 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC1.9) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | FC, IP |
| AMRe60075 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC2.112) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA, FC, IP |
| AMRe60076 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC2.315) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA, FC, IP |
| AMRe60077 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC2.550B) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | FC |
| AMRe60078 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC2.74) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA, FC |
| AMRe60079 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC2.82) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA, FC, IP |
| AMRe60080 | CHIKV p130/Structural polyprotein Recombinant Antibody (DC2.85) | p130, Structural polyprotein | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | FC |
| AMRe60081 | CHIKV Spike glycoprotein E2 Recombinant Antibody (4J21) | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA |
| AMRe60082 | CHIKV Spike glycoprotein E2 Recombinant Antibody (5F10) | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV), Chikungunya virus (strain Nagpur) (CHIKV), Chikungunya virus (strain 37997) (CHIKV) | IgG1, kappa | ELISA, IF, WB |
| AMRe60083 | CHIKV Spike glycoprotein E2 Recombinant Antibody (5M16) | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA |
| AMRe60084 | CHIKV Spike glycoprotein E2 Recombinant Antibody (CHK265) | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1, kappa | ELISA, FC |
| AP Rab60085 | CHIKV Spike glycoprotein E1 Rabbit Polyclonal Antibody | CHIKV-E1 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG | WB, IHC, ELISA |
| AMM60086 | CHIKV Spike glycoprotein E2 Mouse Monoclonal Antibody | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG2b | ELISA |
| AMM60087 | CHIKV Spike glycoprotein E2 Mouse Monoclonal Antibody | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1 | ELISA |
| AMM60088 | CHIKV Spike glycoprotein E2 Mouse Monoclonal Antibody | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1 | ELISA |
| AMM60089 | CHIKV Spike glycoprotein E2 Mouse Monoclonal Antibody | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG2b | WB, ELISA |
| AMM60090 | CHIKV Spike glycoprotein E2 Mouse Monoclonal Antibody | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG2a | WB, ELISA |
| AMM60091 | CHIKV Spike glycoprotein E2 Mouse Monoclonal Antibody | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG2b | ELISA |
| AP Rab60092 | CHIKV Spike glycoprotein E2 Rabbit Polyclonal Antibody | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG | WB |
| AMM60093 | CHIKV Spike glycoprotein E2 Mouse Monoclonal Antibody | Structural polyprotein, Envelope glycoprotein E2, Spike glycoprotein E2 | Chikungunya virus (strain S27-African prototype) (CHIKV) | IgG1 | ELISA |
